A novel approach to studying the human brain

Building three-dimensional human brain organoids

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Scientists have developed a novel approach to study the human brain. Pluripotent stem cells are cultivated into organoids or neural tissues and differentiated to represent specific regions of the brain and nervous system called brain assembloids. These 3D cultured cells will allow researchers to explore the onset of diseases, psychiatric disorders and neurological conditions in humans. In addition, the brain assembloids will assist researchers understand the evolution of the human brain and how it develops and matures in individuals. In future, the research technique will aid the identification of genetic markers (using CRSPR technology) to target the application of therapeutic treatments.  

The poster is free to download. It was created by Sergiu Pasca from the Department of Psychiatry and Behavioral Sciences, Stanford University, and published via Nature Neuroscience online with support by Stemcell Technologies. 

Building three-dimensional human brain organoids

Gabrielle Ahern

Managing Editor, npj Science of Learning Community

I am based in Queensland, Australia, and have an interesting portfolio of skills, experience and qualifications in science research and content creation. 


Go to the profile of Margie Meacham
over 3 years ago

How do we know these models are really accurate? Is there any risk of losing fidelity through this process?

Go to the profile of Gabrielle Ahern
over 3 years ago

I understand where you are coming from and with the design of any experiment there are always going to be questions about whether it is appropriate or will it answer research questions. Without the application of such innovative techniques though, how will researchers advance their knowledge. This type of technique might also work to inspire other avenues for scientists to explore.